Pemetrexed disodium is a antifolate antimetabolite which potently inhibits dihydrofolate reductase (DHFR), thymidylate synthase (TS), and glycinamide ribonucleotide formyltransferase (GARFT) with Ki values of 7.0 nM, 109 nM and 9,300 nM, respectively. Pemetrexed disodium is active as an inhibitor of tumor growth in vitro and in vivo.

KEYWORDS: Pemetrexed disodium | supplier | DHFR/TS/GARFT inhibitor | LY231514 disodium | LY 231514 disodium | LY-231514 disodium | CAS [137281-23-3] | [150399-23-8] | Deoxyuridine monophosphate (dUMP) | TYMS | Inhibitor | Enzymes | Alimta