TL02-59 is a potent, selective and orally active inhibitor of Fgr and Lyn kinase with IC50 values of 0.03 nM and 0.10 nM, respectively. TL02–59 exhibits pM potency against the AML-associated Src-family kinase, Fgr, both in vitro and in cell-based kinase assays. TL02–59 inhibited the growth and induced apoptosis of AML cell lines expressing this kinase with single-digit nM potency. More importantly, TL02–59 induced growth arrest in primary AML bone marrow samples, with Fgr expression correlating most strongly with TL02–59 sensitivity.

KEYWORDS: TL02-59 | Supplier | Fgr/Lyn inhibitor | TL 02-59 | TL-02-59 | TL 0259 | TL-0259 | TL0259 | CAS [1315330-17-6] | Non Selective (Phosphorylation Substrates) | SRC | Inhibitor | Enzymes | Acute myelogenous leukemia | AML