TL02-59

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 3099

CAS [1315330-17-6]

MF C32H34F3N5O4
MW 609.64

  • Purity: 99%
  • Soluble in DMSO
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TL02-59

Description

TL02-59 is a potent, selective and orally active inhibitor of Fgr and Lyn kinase with IC50 values of 0.03 nM and 0.10 nM, respectively. TL02–59 exhibits pM potency against the AML-associated Src-family kinase, Fgr, both in vitro and in cell-based kinase assays. TL02–59 inhibited the growth and induced apoptosis of AML cell lines expressing this kinase with single-digit nM potency. More importantly, TL02–59 induced growth arrest in primary AML bone marrow samples, with Fgr expression correlating most strongly with TL02–59 sensitivity.

KEYWORDS: TL02-59 | Supplier | Fgr/Lyn inhibitor | TL 02-59 | TL-02-59 | TL 0259 | TL-0259 | TL0259 | CAS [1315330-17-6] | Non Selective (Phosphorylation Substrates) | SRC | Inhibitor | Enzymes | Acute myelogenous leukemia | AML

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5 mg €120.00 In Stock
25 mg €430.00 In Stock
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2 x 5 mg €200.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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