Amiselimod hydrochloride is a prodrug sphingosine 1-phosphate (S1P) receptor modulator. Amiselimod is converted to its active metabolite, (S)-amiselimod phosphate (amiselimod-P), by sphingosine kinases. Amiselimod-P showed potent selectivity for S1P1 and high selectivity for S1P5 receptors, with minimal agonist activity for S1P4 and no distinct agonist activity for S1P2 or S1P3 receptors and approximately five-fold weaker GIRK activation than fingolimod-P.

KEYWORDS: Amiselimod hydrochloride | supplier | S1PR modulator | MT-1303 | MT1303 | MT 1303 | CAS [942398-84-7] | [942399-20-4] | Sphingosine-1-phosphate | S1PR | Modulator | Receptors | Multiple sclerosis | Autoimmune disease | Bradycardia