NSC 95397 is a potent and selective Cdc25 dual specificity phosphatase (DUSP) inhibitor with in vitro Ki values of 32, 96, and 40 nM for Cdc25A, -B, and -C, respectively. NSC 95397 was 125- to 180-fold more selective for Cdc25A than VH1-related dual-specificity phosphatase or protein tyrosine phosphatase 1b, respectively. Moreover, NSC 95397 showed significant growth inhibition against human and murine carcinoma cells and blocked G(2)/M phase transition.

KEYWORDS: NSC 95397 | supplier | Cdc25 inhibitor | NSC95397 | NSC-95397 | CAS [93718-83-3] | Non Selective (Serine-Threonine and Tyrosine Specific Phosphodiesters) | DUSP | Inhibitor | Enzymes | Cell cycle progression | Cdk | Carcinoma