CCG-222740

Based on 4 reference(s) in Google Scholar 8 10 4

Axon 3069

CAS [1922098-69-8]

MF C23H19ClF2N2O3
MW 444.86

  • Purity: 98%
  • Soluble in DMSO
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CCG-222740

Description

CCG-222740 is a potent and selective second-generation MRTF/SRF inhibitor with an IC50 value of 5 μM in a fibroblast-mediated collagen contraction assay. CCG-222740 is more potent at preventing alpha-smooth muscle actin protein expression, is less cytotoxic, and effectively prevents scar tissue formation in a preclinical model of fibrosis (vs CCG-203971).

KEYWORDS: CCG-222740 | supplier | Rho/MRTF/SRF inhibitor | CCG222740 | CCG 222740 | CAS [1922098-69-8] | Non Selective (Phosphorylation Substrates) | ROCK | Inhibitor | Enzymes | Scar tissue | Antifibrotic | Systemic scleroderma

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Size Unit Price Stock
5 mg €145.00 In Stock
25 mg €545.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €240.00 In Stock
2 x 25 mg €800.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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