HOIPIN 11a - GSK11a

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 3064

CAS [1610800-91-3]

MF C15H18N2O4
MW 290.31

  • Purity: 99%
  • Soluble in DMSO

HOIPIN 11a

Description

Selective, cell-permeable and covalent inhibitor of the RBR E3 ubiquitin ligase HOIP. Biochemical characterization of HOIPIN 11a demonstrated that this compound labels HOIP with promising proteome-wide selectivity and effectively inhibits linear polyubiquitin chain formation in vitro and in a cellular environment. Treating HEK293T cells overexpressing full length HOIP, HOIL-1L, and SHARPIN with compound 11a overnight led to inhibition of NF-κB activation in a concentration-dependent manner, with an estimated IC50 value of 37 μM.

KEYWORDS: HOIPIN 11a | supplier | HOIP inhibitor | GSK11a | GSK 11a | GSK-11a | CAS [1610800-91-3] | NF-κB Pathway | Ubiquitin Ligase (E3; LUBAC) | Inhibitor | Enzymes | HOIL-1L | SHARPIN | E3 ligase

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5 mg €180.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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