RBPJ inhibitor RIN1 is a potent, selective, first-in-class inhibitor of the transcription factor RBPJ. RBPJ inhibitor RIN1 inhibits RBPJ in both its activating (NOTCH) and inhibiting (SHARP) complexes. Consistent with disruption of NOTCH signaling, RBPJ inhibitor RIN1 inhibited the proliferation of hematologic cancer cell lines and promoted skeletal muscle differentiation from C2C12 myoblasts.

KEYWORDS: RBPJ inhibitor RIN1 | Supplier | RBPJ inhibitor | RIN1 | RIN 1 | RIN-1 | RBPJ Inhibitor 1 | CAS [2682114-39-0] | DNA-RNA | RBPJ | Inhibitor | Transcription Factors | CBF1 | KBF2 | CSL | NOTCH | SHARP