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Axon 3053
CAS [2244904-70-7]
MF C25H28N4O2SMW 448.58
BAY-293 is a potent, selective and cell-active inhibitor of KRAS-SOS1 interaction with an IC50 value of 21 nM. BAY-293 efficiently inhibited pERK levels in K-562 cells after incubation for 60 min without affecting total protein levels of ERK. A synergistic effect is observed between BAY-293 and ARS-853 in a KRASG12C-mutated cancer cell line.
KEYWORDS: BAY-293 | supplier | KRAS-SOS1 inhibitor | BAY293 | BAY 293 | CAS [2244904-70-7] | GTP | KRAS | Inhibitor | Enzymes | Son of sevenless | SOS1
(R)-6,7-Dimethoxy-2-methyl-N-(1-(4-(2-((methylamino)methyl)phenyl)thiophen-2-yl)ethyl)quinazolin-4-amine
[2244904-70-7]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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