ADH-503 - Leukadherin-1 choline salt | LA1

Based on 9 reference(s) in Google Scholar 8 10 9

Axon 3048

CAS [2055362-74-6]

MF C22H14NO4S2.C5H14NO
MW 524.65

  • Purity: 99%
  • Soluble in DMSO
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ADH-503

Description

ADH-503 is an allosteric agonist of integrin CD11b/CD18 (also known as Mac-1) with an EC50 value of 4 mM. ADH-503 suppresses myeloid cell infiltration into inflamed or infected sites by increasing CD11b-dependent cell adhesion to ICAM-1 on the endothelium, preventing subsequent extravasation. Moreover, partial activation of CD11b by ADH-503 leads to the repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhanced dendritic cell responses.

KEYWORDS: ADH-503 | supplier | CD11b/CD18 agonist | Leukadherin-1 choline salt | LA1 | ADH503 | ADH 503 | CAS [2055362-74-6] | [2055362-72-4] | iC3b/C4b | CD11b/CD18 | Allosteric agonist | Receptors | ITGAM | Integrin alpha M | CR3 | Mac-1 | Macrophage-1 antigen

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Size Unit Price Stock
5 mg €120.00 In Stock
25 mg €330.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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