Barnidipine hydrochloride - YM 09730-5 | Mepirodipine hydrochloride

Based on 193 reference(s) in Google Scholar 8 10 193

Axon 3014

CAS [104757-53-1]

MF C27H29N3O6.HCl
MW 528.00

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

Barnidipine hydrochloride

Description

Barnidipine hydrochloride is a potent calcium antagonist with a Ki value of 0.205 nM. Barnidipine hydrochloride produces its antihypertensive effect by selective blockade of calcium ion influx via the L-subtype ‘voltage-operated’ channels in the excitable membranes of vascular smooth muscle cells, as a result of interaction with specific L-type calcium channel receptors.

HS Malhotra et al. Barnidipine. Drugs. 2001;61(7):989-96; discussion 997-8.

K Tamazawa et al. Stereoselectivity of a potent calcium antagonist, 1-benzyl-3-pyrrolidinyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate. J Med Chem. 1986 Dec;29(12):2504-11.

Cardiovascular Non Selective Antihypertensive agents

Potent Ca2+ channel blocker (L-type voltage gated)

Chemical name

(S)-3-((S)-1-Benzylpyrrolidin-3-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride

Parent CAS No.

[104713-75-9]

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Barnidipine hydrochloride - YM 09730-5 | Mepirodipine hydrochloride

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Barnidipine hydrochloride - YM 09730-5 | Mepirodipine hydrochloride

Description

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