GSK 8612 is a potent and highly selective TBK1 inhibitor (pIC50 value of 6.8). In cellular assays, GSK 8612 inhibited toll-like receptor (TLR)3-induced interferon regulatory factor (IRF)3 phosphorylation in Ramos cells and type I interferon (IFN) secretion in primary human mononuclear cells. In THP1 cells, GSK 8612 was able to inhibit secretion of interferon beta (IFNβ) in response to dsDNA and cGAMP, the natural ligand for STING.

KEYWORDS: GSK 8612 | supplier | TBK1 inhibitor | GSK8612 | GSK-8612 | CAS [2361659-62-1] | Phosphatidylinositol | TBK | Inhibitor | Enzymes | Immunity | Neuroinflammation | Obesity | Cancer