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Axon 3007
CAS [2361659-62-1]
MF C17H17BrF3N7O2SMW 520.33
GSK 8612 is a potent and highly selective TBK1 inhibitor (pIC50 value of 6.8). In cellular assays, GSK 8612 inhibited toll-like receptor (TLR)3-induced interferon regulatory factor (IRF)3 phosphorylation in Ramos cells and type I interferon (IFN) secretion in primary human mononuclear cells. In THP1 cells, GSK 8612 was able to inhibit secretion of interferon beta (IFNβ) in response to dsDNA and cGAMP, the natural ligand for STING.
KEYWORDS: GSK 8612 | supplier | TBK1 inhibitor | GSK8612 | GSK-8612 | CAS [2361659-62-1] | Phosphatidylinositol | TBK | Inhibitor | Enzymes | Immunity | Neuroinflammation | Obesity | Cancer
4-((5-Bromo-2-(3-methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-ylamino)pyrimidin-4-ylamino)methyl)benzenesulfonamide
[2361659-62-1]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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