Based on 4 reference(s) in Google Scholar 8 10 4

Axon 3002

CAS [1361227-90-8]

MF C20H16Cl3N3O4
MW 468.72

  • Purity: 99%
  • Soluble in 0.1N NaOH(aq) and DMSO



JH-RE-06 is a compound disrupting REV1-POL ζ-mediated mutagenic translesion synthesis (TLS). Binding of JH-RE-06 induces REV1 dimerization, which blocks the REV1-REV7 interaction (IC50 value of 0.78 μM) and POL ζ recruitment. JH-RE-06 sensitizes tumors to cisplatin and reduces mutagenesis in vitro. Moreover, JH-RE-06 suppresses tumor progression in mice and prolongs animal survival.

KEYWORDS: JH-RE-06 | supplier | REV1-REV7 inhibitor | CAS [1361227-90-8] | DNA-RNA | DNA | Inhibitor | Enzymes

Specific and in vivo active REV1-REV7 interaction inhibitor

Chemical name


Parent CAS No.


Size Unit Price Stock
5 mg €145.00 In Stock
25 mg €545.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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