Fendiline hydrochloride

Based on 452 reference(s) in Google Scholar 8 10 452

Axon 2829

CAS [13636-18-5]

MF C23H26ClN
MW 351.91

  • Purity: 99%
  • Soluble in DMSO

Fendiline hydrochloride

Description

Fendiline, an L-type calcium channel blocker (IC50 value of 17 µM), is a specific inhibitor of K-Ras plasma membrane targeting (IC50 value of 9.64 µM) with no detectable effect on the localization of H- and N-Ras. Moreover, Fendiline blocked the proliferation of pancreatic, colon, lung, and endometrial cancer cell lines expressing oncogenic mutant K-Ras.

KEYWORDS: Fendiline hydrochloride | supplier | KRAS inhibitor | CAS [13636-18-5] | [13042-18-7] | GTP | KRAS | Inhibitor | Enzymes | Calcium Channel blocker | Ca2+ | GTPase | K-Ras

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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