C-DIM5 is a Nur77 agonist. Activation of the orphan nuclear receptor Nur77 by C-DIM5 is associated with decreased cancer cell survival, induction of apoptosis, induced expression of the apoptosis gene/protein TRAIL, and inhibited tumor growth in vivo. C-DIM5 induces G0-G1–phase to S-phase arrest in Panc1 cells, and this is accompanied by Nur77-dependent induction of the cyclin-dependent kinase inhibitor p21.

KEYWORDS: C-DIM5 | supplier | Nur77 agonist | DIM-C-pPhOCH3 | CDIM5 | CAS [33985-68-1] | Intracellular Transcription Factors | Nurr | Agonist | Receptors | TRAIL