Potent and selective inhibitor of the protein-protein interaction of Mcl-1 and Bim with an IC50 value of 0.31 µM for Mcl-1. ML 311 displayed significant activity in a number of cell lines, with EC50 values in the range of 0.3–15 M. Useful tool for studying lymphoid tumorigenesis and to demonstrate the potential for using this strategy in therapies intended to bypass apoptosis resistance pathways that are activated in drug-resistant tumors.

Keywords: ML 311 | supplier | Mcl-1-Bim interaction inhibitor | ML311 | ML-311 | CAS [315698-17-0] | Non Selective | Mcl-1 | Inhibitor | Proteins | Lymphoid Tumorigenesis | Bim