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Axon 2819
CAS [1395946-75-4]
MF C17H17N3O.HClMW 315.80
APX-115 is a first-in-class pan-NADPH oxidase (Nox) inhibitor with a Ki value of 0.57–1.08 μM for Nox isozymes. Blocking the activity of Nox with APX-115 inhibited the responses of BMMs to RANKL, including reactive oxygen species (ROS) generation, activation of mitogen-activated protein (MAP) kinases and NF-κB, and OC differentiation. Drug candidate for treatment of osteoporosis. Promising therapeutic for diabetic nephropathy.
KEYWORDS: APX-115 | supplier | Nox inhibitor | Ewha-18278 | APX115 | APX 115 | Ewha18278 | Ewha 18278 | CAS [1395946-75-4] | [1270084-92-8] | NADPH | NADPH | Inhibitor | Enzymes | Osteoporosis | Diabetic nephropathy
3-Phenyl-4-propyl-1-(pyridin-2-yl)-1H-pyrazol-5-ol hydrochloride
[1270084-92-8]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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