APX-115 - Ewha-18278

Based on 4 reference(s) in Google Scholar 8 10 4

Axon 2819

CAS [1395946-75-4]

MF C17H17N3O.HCl
MW 315.80

  • Purity: 99%
  • Soluble in DMSO
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APX-115

Description

APX-115 is a first-in-class pan-NADPH oxidase (Nox) inhibitor with a Ki value of 0.57–1.08 μM for Nox isozymes. Blocking the activity of Nox with APX-115 inhibited the responses of BMMs to RANKL, including reactive oxygen species (ROS) generation, activation of mitogen-activated protein (MAP) kinases and NF-κB, and OC differentiation. Drug candidate for treatment of osteoporosis. Promising therapeutic for diabetic nephropathy.

KEYWORDS: APX-115 | supplier | Nox inhibitor | Ewha-18278 | APX115 | APX 115 | Ewha18278 | Ewha 18278 | CAS [1395946-75-4] | [1270084-92-8] | NADPH | NADPH | Inhibitor | Enzymes | Osteoporosis | Diabetic nephropathy

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5 mg €125.00 In Stock
25 mg €425.00 In Stock
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2 x 5 mg €180.00 In Stock
2 x 25 mg €600.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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