ER-819762

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 2788

CAS [1155773-15-1]

MF C30H39N3O3
MW 489.65

  • Purity: 99%
  • Optical purity: >98% ee
  • Soluble in DMSO

ER-819762

Description

ER-819762 is a highly selective, and orally available antagonist of the prostaglandin EP4 receptor (IC50 value of 70 nM). Oral administration of ER-819762 to DBA/1 mice can effectively suppress disease in collagen-induced arthritis (CIA) or glucose-6-phosphate isomerase (GPI)-induced arthritis models. ER-819762 was also effective in treating chronic inflammatory pain in a rat model.

KEYWORDS: ER-819762 | supplier | PGE receptor 2 (EP4) antagonist | ER819762 | ER 819762 | CAS [1155773-15-1] | CAS [1155772-64-7] | Prostaglandins | PGE2 (EP4) | PGE receptor 2 (EP4) | Antagonist | Receptors | Arthritis | Chronic inflammatory pain 

Highly selective, and orally available PGE2 receptor EP4 antagonist

Chemical name

(S,Z)-1'-(3,5-Dimethylbenzyl)-2-ethyl-7,9-dimethoxy-10-methyl-5,10-dihydrospiro[benzo[e]imidazo[1,5-a]azepine-1,4'-piperidin]-3(2H)-one

Parent CAS No.

[1155773-15-1]

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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