T0901317 is selective liver X receptor (LXR) agonist (EC50 value of 20 nM). Oral administration of T0901317 to mice and hamsters showed that LXR activated the coordinate expression of major fatty acid biosynthetic genes (lipogenesis) and increased plasma triglyceride and phospholipid levels in both species. Complementary studies in cell culture and animals suggested that the increase in plasma lipids occurs via LXR-mediated induction of the sterol regulatory element-binding protein 1 (SREBP-1) lipogenic program.

KEYWORDS: T0901317 | supplier | LXR agonist | T 0901317 | T-0901317 | CAS [293754-55-9] | Metabolism | LXR | Agonist | Receptors | Liver X Receptor | Lipogenesis