SEA0400 is a potent and selective inhibitor of the Na+-Ca2+ exchanger (NCX). IC50 values of SEA0400 were 33, 5.0, 8.3, 90 and 92 nM in cultured neurons, astrocytes, microglia, dog sarcolemmal vesicles and cultured rat myocytes, respectively. SEA0400 protects astrocytes against Ca2+ paradox-like injury and reduces cerebral ischemic damage in rats with a transient middle cerebral artery occlusion.

KEYWORDS: SEA0400 | supplier | NCX inhibitor | SEA 0400 | SEA-0400 | CAS [223104-29-8] | Non Selective (Ions; Na+Ca2+) | NCX | Inhibitor | Proteins