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Axon 2745
CAS [1446502-11-9]
MF C19H17F6N7OMW 473.37
AG-221 (Enasidenib) is an oral, selective, first-in-class inhibitor of the mutant IDH2 enzyme (IC50 value of 100 nM). AG-221 demonstrates excellent pharmaceutical properties, including adequate solubility, low clearance, and good oral bioavailability, and potently inhibits 2HG production by both the IDH2R140Q/WT heterodimer and IDH2R140Q homodimer. AG-221 suppressed 2HG production and induced cellular differentiation in primary human IDH2 mutation–positive acute myeloid leukaemia (AML) cells ex vivo and in xenograft mouse models.
KEYWORDS: AG-221 | supplier | IDH2 inhibitor | Enasidenib | AG 221 | AG221 | CAS [1446502-11-9] | Isocitrate | IDH | Inhibitor | Enzymes
2-Methyl-1-(4-(6-(trifluoromethyl)pyridin-2-yl)-6-(2-(trifluoromethyl)pyridin-4-ylamino)-1,3,5-triazin-2-ylamino)propan-2-ol
[1446502-11-9]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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