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Axon 2739
CAS [2092923-21-0]
MF C24H17ClF2N2O2MW 438.85
VU6008667 is a selective negative allosteric modulator (NAM) of M5 muscarinic acetylcholine receptor (mAChR) with IC50 values of 1.2 and 1.6 μM in human and rat M5, respectively. Moreover, VU6008667 has high CNS penetration and shows a desired short half-life in rat (t1/2 = 2.3 h) useful for addiction studies.
KEYWORDS: VU 6008667 | supplier | M5 NAM | VU6008667 | VU-6008667 | CAS [2092923-21-0] | Acetylcholine | CHRM5 | NAM | Receptors | Addiction | Muscarinic
(S)-9b-(4-Chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one
[2092923-21-0]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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