ICA-069673

Based on 7 reference(s) in Google Scholar 8 10 7

Axon 2724

CAS [582323-16-8]

MF C11H6ClF2N3O
MW 269.63

  • Purity: 99%
  • Soluble in DMSO
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ICA-069673

Description

ICA-069673, a Kv7.2/Kv7.3 (KCNQ2/Q3) channel opener (EC50 value 0.69 μM), demonstrated 20-fold greater selectivity for heteromeric Kv7.2/Kv7.3 channels over Kv7.3/Kv7.5. Moreover, compared to retigabine (Axon 1525), ICA-069673 exhibits much stronger effects on KCNQ2 channels, including a large hyperpolarizing shift of the voltage-dependence of activation, an ~2-fold enhancement of peak current and pronounced subtype specificity for KCNQ2 over KCNQ3. Orally active in several animal models of epilepsy.

KEYWORDS: ICA-069673 | supplier | KCNQ channel opener | ICA069673 | ICA 069673 | CAS [582323-16-8] | Potassium | Kv7.2 | Kv7.3 | Opener | Ion Channels | KCNQ2 | KCNQ3 | Anti-convulsant | KCNQ2/Q3

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Size Unit Price Stock
10 mg €90.00 In Stock
50 mg €300.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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