Based on 1 reference(s) in Google Scholar 8 10 1

Axon 2714

CAS [1818389-84-2]

MF C27H24F3N5O2
MW 507.51

  • Purity: 99%
  • Soluble in DMSO



SPHINX31 is a highly potent, selective, and cell active SRPK1 inhibitor (IC50 value of 6 nM). Treatment with this inhibitor inhibited SRPK1 activity and phosphorylation of serine/arginine splicing factor 1 (SRSF1), resulting in alternative splicing of VEGF-A from pro-angiogenic to antiangiogenic isoforms. This property resulted in potent inhibition of blood vessel growth in models of choroidal angiogenesis in vivo.

KEYWORDS: SPHINX31 | supplier | SRPK1 inhibitor | SPHINX 31 | SPHINX-31 | CAS [1818389-84-2] | DNA-RNA | SRPK | Inhibitor | Enzymes | Neovascular Eye Disease | VEGF | SRSF1

Size Unit Price Stock
10 mg €125.00 In Stock
50 mg €475.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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