HLCL65 hydrochloride

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2710

CAS [N.A.]

MF C23H23BrN2O.HCl
MW 459.81

  • Purity: 99%
  • Soluble in DMSO
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HLCL65 hydrochloride

Description

HLCL65 is a highly selective small molecule PRMT5 inhibitor. HLCL65 inhibited Th1 cell proliferation (IC50 value 1.1 μM) more potently than Th2 cell proliferation (IC50 value 4 μM). In vivo, PRMT5 blockade efficiently suppressed recall T cell responses and reduced inflammation in delayed-type hypersensitivity and clinical disease in experimental autoimmune encephalomyelitis mouse models.

HLCL65 is a more potent and bioavailable derivative of CMP5 (Axon 2709).

KEYWORDS: HLCL65 hydrochloride | supplier | PRMT5 inhibitor | HLCL-65 | HLCL 65 | CAS [1627865-11-5] | Non Selective (Arginine Sites Proteins) | PRMT | Inhibitor | Enzymes

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10 mg €105.00 In Stock
50 mg €365.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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