HLCL65 is a highly selective small molecule PRMT5 inhibitor. HLCL65 inhibited Th1 cell proliferation (IC50 value 1.1 μM) more potently than Th2 cell proliferation (IC50 value 4 μM). In vivo, PRMT5 blockade efficiently suppressed recall T cell responses and reduced inflammation in delayed-type hypersensitivity and clinical disease in experimental autoimmune encephalomyelitis mouse models.

HLCL65 is a more potent and bioavailable derivative of CMP5 (Axon 2709).

KEYWORDS: HLCL65 hydrochloride | supplier | PRMT5 inhibitor | HLCL-65 | HLCL 65 | CAS [1627865-11-5] | Non Selective (Arginine Sites Proteins) | PRMT | Inhibitor | Enzymes