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Axon 2703
CAS [100872-83-1]
MF C14H12N2O4MW 272.26
ML346 is an activator of Hsp70 (EC50 value of 4.6 μM; HeLa cell toxicity assay). ML346 induces HSF-1-dependent chaperone expression and restores protein folding in conformational disease models. These effects are mediated by novel mechanisms involving FOXO, HSF-1, and Nfr-2. ML346 has good chemical stability, is not reactive with excess glutathione, and is cell permeable.
KEYWORDS: ML346 | supplier | Hsp70 activator | CID 767276 | ML 346 | ML-346 | CID767276 | CID-767276 | CAS [100872-83-1] | CAS [1423118-63-1] | Unfolded Protein Response (Non Selective) | Hsp70 | Activator | Enzymes | ARE | Heat Shock Response | HSR | Probe | Proteostasis | HSF-1
5-(3-(4-Methoxyphenyl)allylidene)pyrimidine-2,4,6(1H,3H,5H)-trione
[100872-83-1]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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