ML346 - CID 767276

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 2703

CAS [100872-83-1]

MF C14H12N2O4
MW 272.26

  • Purity: 100%
  • Soluble in DMSO
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ML346

Description

ML346 is an activator of Hsp70 (EC50 value of 4.6 μM; HeLa cell toxicity assay). ML346 induces HSF-1-dependent chaperone expression and restores protein folding in conformational disease models. These effects are mediated by novel mechanisms involving FOXO, HSF-1, and Nfr-2. ML346 has good chemical stability, is not reactive with excess glutathione, and is cell permeable.

KEYWORDS: ML346 | supplier | Hsp70 activator | CID 767276 | ML 346 | ML-346 | CID767276 | CID-767276 | CAS [100872-83-1] | CAS [1423118-63-1] | Unfolded Protein Response (Non Selective) | Hsp70 | Activator | Enzymes | ARE | Heat Shock Response | HSR | Probe | Proteostasis | HSF-1

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Size Unit Price Stock
10 mg €125.00 In Stock
50 mg €425.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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