CCT251236

Based on 2 reference(s) in Google Scholar 9 10 2

Axon 2699

CAS [1693731-40-6]

MF C32H32N4O5
MW 552.62

  • Purity: 99%
  • Soluble in 0.1N HCl(aq) and DMSO

CCT251236

Description

Highly potent, orally bioavailable inhibitor of the HSF1 stress pathway. CCT251236 displayed the desired balance of in vitro properties, while maintaining excellent cellular activity for inhibition of HSF1-mediated HSP72 induction (IC50 value of 19 nM). Moreover, CCT251236 displayed efficacy in a human ovarian carcinoma xenograft model. Promising chemical probe to investigate the role of HSF1 pathway inhibition and pirin binding in vitro and in vivo.

KEYWORDS: CCT251236 | supplier | HSF1 inhibitor | CCT 251236 | CCT-251236 | CAS [1693731-40-6] | DNA-RNA | HSF1 | Inhibitor | Transcription Factors | HSP72 | Pirin

Order
Size Unit Price Stock
5 mg €145.00 In Stock
25 mg €525.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €220.00 In Stock
2 x 25 mg €860.00 In Stock
Need more? Bulk Inquiry

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...