Brain penetrant ERβ-selective agonist (IC50 values 155 nM and 2 nM for ERα and ERβ, respectively) that increases key synaptic proteins in vivo, including PSD-95, synaptophysin and the AMPA-receptor subunit GluR1 and increases dendritic branching and spine number. WAY 20070 regulates hippocampal synaptic plasticity and improve hippocampus-dependent cognition, and shows antidepressant and anxiolytic-like effects in vivo. Potential novel therapeutic agent for the prevention and treatment of photoaging.

KEYWORDS: WAY-200070 | supplier | ERβ agonist | WAY-00005 | WAY200070 | WAY 200070 | WAY00005 | WAY 00005 | CAS [440122-66-7] | Axon Medchem | Axon 2697 | Estrogen | Nuclear Receptor | Brain penetrant | PSD-95 | synaptophysin | AMPA | GluR1 | dendritic branching | synaptic plasticity | cognition | antidepressant | anxiolytic