LRE1 is an allosteric soluble adenylyl cyclase (sAC)-specific inhibitor (IC50 value ≤ 10μM). Inhibition occurs by occupying the binding site of the physiological activator HCO3-, preventing sAC-dependent processes in cellular and physiological systems. LRE1 also inhibited cAMP accumulation in 4-4 cells (IC50 value 11 μM). Overall, this sAC inhibitor combines high potency and selectivity with stability, solubility and lack of cytotoxicity.

KEYWORDS: LRE1 | Allosteric sAC inhibitor | supplier | RU-0204277 | LRE 1 | LRE-1 | RU 0204277  | RU0204277  | CAS [1252362-53-0] | ATP | Adenylate cyclase | Inhibitor | Enzymes