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Axon 2654
CAS [315703-52-7]
MF C19H18N4OSMW 350.44
Antagonist of Hedgehog (Hh) signaling (IC50 value of 30 nM for inhibition of Gli-dependent transcriptional activity) and a potent inhibitor of microtubule assembly that exhibits good antiproliferative activity both in vitro and in vivo. JK184 appears to act by inhibition of Adh7 (Kd value 210 nM in a assay for enzymatic oxidation of retinol).
KEYWORDS: JK184 | supplier | Hedgehog inhibitor | JK-184 | CAS [315703-52-7] | [466638-53-9] | Hedgehog | ADH | Antagonist | Hh | Smoothened | Smo | Patched | Ptch1 | Ptc | Gli | microtubules | Sonic | shh | Indian | ihh | Desert | dhh
N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
[315703-52-7]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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