HSF1 inhibitor (IC50 value 1.2 µM for inhibition of heat shock-induced luciferase activity). KRIBB11 blocks the induction of HSF1 downstream target proteins such as HSP27 and HSP70, and induces growth arrest and apoptosis in HCT-116 cells. KRIBB11 inhibits HSF1-dependent recruitment of positive transcription elongation factor b (p-TEFb) to the hsp70 promoter, and tumor growth is inhibited without body weight loss upon intraperitoneal treatment of nude mice with KRIBB11. KRIBB11 enhances the cytotoxicity of nocodazole and parbendazole.

KEYWORDS: KRIBB11 | supplier | HSF1 inhibitor | CAS [342639-96-7] | KRIBB 11 | DNA-RNA | HSF1 | Inhibitor | Transcription Factor | heat sock factor |HSP27 | HSF70 | apoptosis | growth arrest | p-TEFb