Based on 74 reference(s) in Google Scholar 9 10 74

Axon 2538

CAS [342639-96-7]

MF C13H12N6O2
MW 284.27

  • Purity: 99%
  • Soluble in DMSO



HSF1 inhibitor (IC50 value 1.2 µM for inhibition of heat shock-induced luciferase activity). KRIBB11 blocks the induction of HSF1 downstream target proteins such as HSP27 and HSP70, and induces growth arrest and apoptosis in HCT-116 cells. KRIBB11 inhibits HSF1-dependent recruitment of positive transcription elongation factor b (p-TEFb) to the hsp70 promoter, and tumor growth is inhibited without body weight loss upon intraperitoneal treatment of nude mice with KRIBB11. KRIBB11 enhances the cytotoxicity of nocodazole and parbendazole.

KEYWORDS: KRIBB11 | supplier | HSF1 inhibitor | CAS [342639-96-7] | KRIBB 11 | DNA-RNA | HSF1 | Inhibitor | Transcription Factor | heat sock factor |HSP27 | HSF70 | apoptosis | growth arrest | p-TEFb

Size Unit Price Stock
10 mg €125.00 In Stock
50 mg €450.00 In Stock
Need more? Bulk Inquiry

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...