AMG 837 calcium salt

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2405

CAS [1291087-14-3]

MF C26H20F3O3.½Ca
MW 457.47

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in DMSO

AMG 837 calcium salt

Description

Orally bioavailable partial agonist of the GPR40 (EC50 value 13.5 nM for AMG 837 stimulated Ca2+ flux in CHO cells expressing human GPR40) with a superior pharmacokinetic profile. AMG837 stimulated robust glucose-dependent insulin secretion (EC50 value 142±20 nM) in isolated rodent islets, and lowered post-prandial glucose in normal rats. AMG-837 exhibits a potential utility for the treatment of type 2 diabetes.
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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