SMI 481 - 6748-481

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2387

CAS [432020-20-7]

MF C17H15ClFN3O3
MW 363.77

  • Purity: 99%
  • Soluble in DMSO

SMI 481

Description

Small-molecule inhibitor (SMI) of the yeast PITP Sec14 (IC50 values of 211 nM and 2.87 μM for Sec14 mediated [3H]PtdIns transfer in vitro, and Sec14 dependent cell growth inhibition of WT (CTY182, gray) strains, respectively). SMI481 (aka 6748-481 ) is a water-soluble bioactive compound exhibiting exquisite pathway selectivity in inhibiting phosphoinositide signaling in cells with >200-fold selectivity over other yeast Sec14-like transfer activities. PITP-​directed SMIs offer new and generally applicable avenues for intervening with phosphoinositide signaling pathways with selectivities superior to those afforded by contemporary lipid kinase-​directed strategies.
First small-molecule inhibitor (SMI) of the yeast PITP Sec14

Chemical name

(4-chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)methanone

Parent CAS No.

[432020-20-7]

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50 mg €300.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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