LXR 623 - WAY 252623

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2357

CAS [875787-07-8]

MF C21H12ClF5N2
MW 422.78

  • Purity: 99%
  • Soluble in DMSO

LXR 623


Partial agonist of Liver X Receptor (LXR; IC50 value 179 nM and 24 nM for LXRα- and LXRβ-binding, respectively. EC50 values 6.66 μM and 3.67 μM for Huh-7 human hepatoma cell based Gal4 LXRα and LXRβ transactivation essays respectively). Despite its partial agonism in transactivation essays, LXR 623 exhibits full agonism in THP-1 cells with respect to increasing ABCA1 gene expression and on cholesterol efflux in THP-1 foam cells. In vivo, LXR 623 lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse.

Size Unit Price Stock
10 mg €95.00 In Stock
50 mg €305.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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