JSH 23

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2349

CAS [749886-87-1]

MF C16H20N2
MW 240.34

  • Purity: 99%
  • Soluble in 0.1N HCl(aq) and DMSO

JSH 23


Inhibitor of NF-κB transcription and nuclear translocation of p65 (IC50 value 7.1 µM for inhibition of LPS-induced NF-κB transcriptional activity) without affecting IκBα degradation, which is a very rare mode of action. JSH 23 inhibited not only LPS-induced expressions of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6 and inducible nitric oxide synthase and cyclooxygenase-2 but also LPS-induced apoptosis of the RAW 264.7 cells.
JSF 23 also inhibits NO production in LPS-stimulated macrophages RAW 264.7 (IC50 value 14.4 µM).

KEYWORDS: JSH 23 | supplier | NF-κB inhibitor | JSH23 | CAS [749886-87-1] | NF-κB | Inhibitor | p65 | IκB | inflammation | transcription factor | Pro-inflammatory | cytokine | LPS | IKK | RAW 264.7 | COX-2

Size Unit Price Stock
10 mg €95.00 In Stock
50 mg €380.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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