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Axon 2342
CAS [1421373-65-0]
MF C28H33N7O2MW 499.61
A potent oral, third-generation EGFR TKI, that irreversibly and selectively targets both sensitizing and resistant T790M+ mutant EGFR while harboring less activity toward wild-type EGFR (IC50 values 1 nM,12 nM, 5 nM, and 184 nM against L858R/T790M-, L858R-, L861Q-mutant, and WT EGFR, respectively).
KEYWORDS: AZD9291 | supplier | EGFR inhibitor | Osimertinib | AZD-9291 | AZD 9291 | CAS [1421373-65-0] | EGF | EGFR | Non-small cell lung cancer | NSCLC | ERBB | HER | T790M | TKI | cancer | oncology
N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)acrylamide
[1421373-65-0]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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