OTX 008 - PTX 008 | Calixarene 0118

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2332

CAS [286936-40-1]

MF C52H72N8O8
MW 937.18

Purity: 99%
Soluble in DMSO and Ethanol

OTX 008

Description

Selective allosteric inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumor angiogenesis. OTX008 inhibited galectin-1 expression and ERK1/2 and Akt-dependent survival pathways, and induced G2/M cell cycle arrest through CDK1.

L. Astorgues-Xerri et al. OTX008, a selective small-molecule inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumour angiogenesis. Eur. J. Cancer. 2014, 50, 2463-2477.

M. Zucchetti et al. Pharmacokinetics and antineoplastic activity of galectin-1-targeting OTX008 in combination with sunitinib. Cancer Chemother. Pharmacol. 2013, 72, 879-887.

R.O. Dings et al. Polycationic calixarene PTX013, a potent cytotoxic agent against tumors and drug resistant cancer. Invest. New Drugs. 2013, 31, 1142-1150.

R.P. Dings et al. Antitumor agent calixarene 0118 targets human galectin-1 as an allosteric inhibitor of carbohydrate binding. J. Med. Chem. 2012, 55, 5121-5129.

Selective allosteric inhibitor of galectin-1

Chemical name

2,2',2'',2'''-[Pentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(25),3,5,7(28),9,11,13(27),15,17,19(26),21,23-dodecaene-5,11,17,23-tetrayltetrakis(oxy)]tetrakis[N-[2-(dimethylamino)ethyl]-acetamide

Parent CAS No.

[286936-40-1]

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OTX 008 - PTX 008 | Calixarene 0118

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OTX 008 - PTX 008 | Calixarene 0118

Description

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