Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2328

CAS [1032822-42-6]

MF C13H17NO3
MW 235.28

  • Purity: 99%
  • Soluble in 0.1N NaOH(aq), DMSO, and Ethanol



Brain penetrating neuroprotectant that attenuates MPTP induced motor deficits, prevents neurodegeneration and suppresses microglial activation in the substantia nigra. Mechanistically, PTIQ effectively suppresses expression of MMP-3 (IC50 value 60 nM in stressed dopaminergic cells), and NO production (IC50 value <100 µM in LPS stimulated BV-2 cells). PTIQ also inhibits IL-1β, TNF-α (IC50 value 6.5 µM) and COX-2 (IC50 value 9.3 µM) and blocked nuclear translocation of NF-κB, yet it shows no inhibition of hERG channels or CYP isozyme activities.
Size Unit Price Stock
10 mg €125.00 In Stock
50 mg €485.00 In Stock
Need more? Bulk Inquiry

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...