First reported, potent and selective inhibitor of the ‘integrated stress response’ (ISR) and a potent inhibitor of PERK signaling. ISRIB potently reverses the effects of eIF2α phosphorylation (IC50 value of 5 nM for inhibition of ATF4-luciferase reporter). Trans-ISRIB reduces the viability of cells subjected to PERK-activation by chronic endoplasmic reticulum stress, and proved to be 100-fold more potent than cis-ISRIB, indicating that the compound’s interaction with its cellular target is stereospecific.

KEYWORDS: ISRIB | supplier | ISR inhibitor | trans-ISRIB | CAS [1597403-47-8] | Unfolded Protein Response (EIF2 Selective) | PERK | Inhibitor | Enzymes

Caution: Axon Ligands™ are for research purposes only! Not intended for human consumption!