ISRIB - trans-ISRIB

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2278

CAS [1597403-47-8]

MF C22H24Cl2N2O4
MW 451.34

  • Purity: 99%
  • Optical purity: Relative stereochemistry
  • Soluble in DMSO and DCM-MeOH

ISRIB

Description

First reported, potent and selective inhibitor of the ‘integrated stress response’ (ISR) and a potent inhibitor of PERK signaling. ISRIB potently reverses the effects of eIF2α phosphorylation (IC50 value of 5 nM for inhibition of ATF4-luciferase reporter).Trans-ISRIB reduces the viability of cells subjected to PERK-activation by chronic endoplasmic reticulum stress, and proved to be 100-fold more potent than cis-ISRIB, indicating that the compound’s interaction with its cellular target is stereospecific.
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10 mg €95.00 In Stock
50 mg €340.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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