TH 588 hydrochloride

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2272

CAS [N.A.]

MF C13H12ClN4.HCl
MW 331.63

  • Purity: 99%
  • Soluble in DMSO

TH 588 hydrochloride

Description

First-in-class MTH1 inhibitor (IC50 value 5.0 nM) that selectively and effectively kills U2OS and other cancer cell lines, with considerably less toxicity towards several primary or immortalized cells. Similar to TH 287, TH 588 shows no relevant inhibitory effect for any of the other tested nudix hydrolase protein family members MTH2, NUDT5, NUDT12, NUDT14, and NUDT16, nor for other proteins with known nucleoside triphosphate pyrophosphatase activity (dCTPase, dUTPase and ITPA).
Replacement of the methyl group by a cyclopropyl substituent in TH 588 (compared to TH 287, Axon 2271) improved metabolic stability both in vitro and in vivo, while maintaining MTH1 potency.

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Size Unit Price Stock
5 mg €95.00 In Stock
25 mg €325.00 In Stock
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Size Unit Price Stock
2 x 5 mg €140.00 In Stock
2 x 25 mg €480.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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