Sulfone inhibitor of PRMT1 (IC50 values 12.75 μM and 26.7 μM for oligopeptide that contains the amino acids 1–21 of human histone H4 and non-histone protein Npl3 as methylation substrates respectively). Useful tool in studying the epigenetic role of PRMT1. PRMT1 has been linked to the activation of estrogen and androgen receptors as well. PRMT1 is a necessary component for oncogenic transformation induced by a mixed lineage leukemia (MLL) complex, and therefore may represent a new treatment option for hormone-dependent cancer.