SB 505124

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2197

CAS [694433-59-5]

MF C20H21N3O2
MW 335.40

  • Purity: 100%
  • Soluble in 0.1N HCl(aq) and DMSO

SB 505124


Selective inhibitor of TGF-β type I receptors ALK4 and ALK5 (IC50 values 129 nM and 47 nM, respectively). SB 505124 also inhibits the closely related ALK7 receptor, but not the BMP activated receptors (ALK1, 2, 3, and 6). It inhibits downstream TGF-β and Activin induced signaling of Smad2, but not BMP induced signaling of Smad1, -5, or -8. Pretreatment of the cells with SB-505124 blocked TGFβ–induced cell death but had no effect on TNFα–induced toxicity. Additionally, SB-505124 blocks activation of TGFβ induced MAPK pathways but is ineffective when these pathways are induced by EGF.
Size Unit Price Stock
5 mg €95.00 In Stock
25 mg €305.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €140.00 In Stock
2 x 25 mg €460.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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