K 02288

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2189

CAS [1431985-92-0]

MF C20H20N2O4
MW 352.38

  • Purity: 99%
  • Soluble in 0.1N HCl(aq) and DMSO

K 02288

Description

Potent and highly selective inhibitor of BMP signaling, with low nanomolar IC50 values of 1.8, 1.1, 6.4 nM for ALK1, ALK2 and ALK6 respectively and IC50s of 34.4, 302, 321 and 220 nM for other ALKs (3, 4, 5) and ActRIIA respectively.K02288 specifically inhibited the BMP-induced Smad pathway without affecting TGF-β signaling and induced dorsalization of zebrafish embryos. K02288 provides a useful tool to investigate BMP signaling and to research into stem cell biology and disease models of anemia, musculoskeletal dysplasia and cancer.
Order
Size Unit Price Stock
5 mg €90.00 In Stock
25 mg €300.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €130.00 In Stock
2 x 25 mg €450.00 In Stock
Need more? Bulk Inquiry

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...