A 804598

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2182

CAS [1125758-85-1]

MF C19H17N5
MW 315.37

  • Purity: 99%
  • Optical purity: >99% e.e.
  • Soluble in DMSO

A 804598

Description

Potent and selective P2X7 antagonist (IC50 values 10 nM, 9 nM, and 11 nM for rat, mouse, and human receptors respectively). A 804598 potently blocked agonist stimulated release of IL-1β and Yo-Pro uptake from differentiated THP-1 cells that natively express human P2X7 receptors.In another study, A 804598 was found to produce a concentration-dependent inhibition of BZ-ATP-stimulated calcium influx (IC50 value 28.71 nM) in cells expressing the rat recombinant P2X7 receptor; a useful tool for autoradiographic localization of P2X7 receptors in the rat brain and spinal cord.
Potent and selective P2X7 antagonist

Chemical name

(S)-2-cyano-1-(1-phenylethyl)-3-(quinolin-5-yl)guanidine

Parent CAS No.

[1125758-85-1]

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10 mg €125.00 In Stock
50 mg €450.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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