A 804598

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2182

CAS [1125758-85-1]

MF C19H17N5
MW 315.37

  • Purity: 99%
  • Optical purity: >99% e.e.
  • Soluble in DMSO

A 804598


Potent and selective P2X7 antagonist (IC50 values 10 nM, 9 nM, and 11 nM for rat, mouse, and human receptors respectively). A 804598 potently blocked agonist stimulated release of IL-1β and Yo-Pro uptake from differentiated THP-1 cells that natively express human P2X7 receptors.In another study, A 804598 was found to produce a concentration-dependent inhibition of BZ-ATP-stimulated calcium influx (IC50 value 28.71 nM) in cells expressing the rat recombinant P2X7 receptor; a useful tool for autoradiographic localization of P2X7 receptors in the rat brain and spinal cord.
Potent and selective P2X7 antagonist

Chemical name


Parent CAS No.


Size Unit Price Stock
10 mg €125.00 In Stock
50 mg €450.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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