Inhibitor of superoxide dismutase 1 (SOD1). Inhibits SOD1 enzymatic activity in vitro (IC50: 0.19 μM for cell growth inhibition in KRAS mutated H358 cell lines). Conversely, (over-) expression of SOD1 cDNA showed about a threefold reduction in sensitivity to LCS-1 and increased proliferation of H358 cells. Additionally, LCS-1 can prevent serum-induced activation of the ERK and PI 3-kinase/AKT signaling pathways.

KEYWORDS: LCS-1 | supplier | SOD1 inhibitor | LCS1 | CAS [41931-13-9] | Superoxide | SOD1 | superoxide dismutase 1 | KRAS | ERK | PI3K | AKT | signaling | lung cancer