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Axon 2176
CAS [41931-13-9]
MF C11H8Cl2N2OMW 255.10
Inhibitor of superoxide dismutase 1 (SOD1). Inhibits SOD1 enzymatic activity in vitro (IC50: 0.19 μM for cell growth inhibition in KRAS mutated H358 cell lines). Conversely, (over-) expression of SOD1 cDNA showed about a threefold reduction in sensitivity to LCS-1 and increased proliferation of H358 cells. Additionally, LCS-1 can prevent serum-induced activation of the ERK and PI 3-kinase/AKT signaling pathways.
KEYWORDS: LCS-1 | supplier | SOD1 inhibitor | LCS1 | CAS [41931-13-9] | Superoxide | SOD1 | superoxide dismutase 1 | KRAS | ERK | PI3K | AKT | signaling | lung cancer
4,5-dichloro-2-m-tolylpyridazin-3(2H)-one
[41931-13-9]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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