LCS-1

Based on 89 publications in PubMed 9 10 89

Axon 2176

CAS [41931-13-9]

MF C11H8Cl2N2O
MW 255.10

  • Purity: 99%
  • Soluble in DMSO

LCS-1

Description

Inhibitor of superoxide dismutase 1 (SOD1). Inhibits SOD1 enzymatic activity in vitro (IC50: 0.19 μM for cell growth inhibition in KRAS mutated H358 cell lines). Conversely, (over-) expression of SOD1 cDNA showed about a threefold reduction in sensitivity to LCS-1 and increased proliferation of H358 cells. Additionally, LCS-1 can prevent serum-induced activation of the ERK and PI 3-kinase/AKT signaling pathways.

KEYWORDS: LCS-1 | supplier | SOD1 inhibitor | LCS1 | CAS [41931-13-9] | Superoxide | SOD1 | superoxide dismutase 1 | KRAS | ERK | PI3K | AKT | signaling | lung cancer

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Size Unit Price Stock
10 mg €85.00 In Stock
50 mg €245.00 In Stock
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2 x 10 mg €120.00 In Stock
2 x 50 mg €360.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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