CX 5461

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2173

CAS [1138549-36-6]

MF C27H27N7O2S
MW 513.61

  • Purity: 99%
  • Soluble in 0.1N HCl(aq)

CX 5461

Description

First selective inhibitor of RNA Polymerase I (Pol I or RNAP1, IC50 of 0.88 μM) transcription with in vivo activity in tumor growth efficacy models; potent and orally bioavailable. CX 5461 demonstrated approximately 200-fold selectivity against Pol I relative to Pol II. It selectively kills tumor cells by activating p53-dependent apoptosis. It also shows potent antiproliferative capacity in human hematologic tumor cells.
Order
Size Unit Price Stock
5 mg €135.00 In Stock
25 mg €475.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €200.00 In Stock
2 x 25 mg €720.00 In Stock
Need more? Bulk Inquiry

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...