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CX 5461

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2173

CAS [1138549-36-6]

MF C27H27N7O2S
MW 513.61

  • Purity: 99%
  • Soluble in 0.1N HCl(aq)

CX 5461

Description

First selective inhibitor of RNA Polymerase I (Pol I or RNAP1, IC50 of 0.88 μM) transcription with in vivo activity in tumor growth efficacy models; potent and orally bioavailable. CX 5461 demonstrated approximately 200-fold selectivity against Pol I relative to Pol II. It selectively kills tumor cells by activating p53-dependent apoptosis. It also shows potent antiproliferative capacity in human hematologic tumor cells.
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5 mg €120.00 In Stock
25 mg €420.00 In Stock
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2 x 5 mg €180.00 In Stock
2 x 25 mg €620.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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