BAY 58-2667 hydrochloride - Cinaciguat hydrochloride

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2172

CAS [646995-35-9]

MF C36H39NO5.HCl
MW 602.16

  • Purity: 99%
  • Soluble in 0.1N NaOH(aq) and DMSO

BAY 58-2667 hydrochloride

Description

Potent nitric oxide (NO)-independent soluble guanylyl cyclase (sGC) activator with haemodynamic effect similar to that of nitroglycerin (Ki value 6-8 nM in competition binding studies). Acts specifically on oxidized/haem-free sGC by binding to the enzyme's haem pocket and mimicking the nitric-oxide-bound haem group. BAY 58-2667 is in clinical development for the treatment of acute decompensated heart failure (ADHF).

KEYWORDS: BAY 58-2667 hydrochloride | supplier | sGC activator | Cinaciguat hydrochloride | BAY58-2667 | CAS [646995-35-9] | [329773-35-5] | GTP | sGC | soluble | guanylyl cyclase | NO | nitric oxide | heart failure | cardiac | ADHF

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Size Unit Price Stock
5 mg €125.00 In Stock
25 mg €425.00 In Stock
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Size Unit Price Stock
2 x 5 mg €180.00 In Stock
2 x 25 mg €660.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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