SJ 172550

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2164

CAS [431979-47-4]

MF C22H21ClN2O5
MW 428.87

  • Purity: 99%
  • Soluble in DMSO

SJ 172550

Description

First small molecule inhibitor of MDMX with 10-fold selectivity over closely related MDM2 (EC50 2.3 μM vs 26.0 μM) which effectively kills MDMX-amplified retinoblastoma cells.
SJ 172550 reversibly binds the p53-binding pocket of MDM, disrupts the MDMX-p53 interaction, and thereby frees p53 to induce apoptosis. The effect of SJ 172550 is additive when combined with an MDM2 inhibitor Nutlin 3a (Axon 1880). It may be useful for treating tumors that express wild-type p53

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Size Unit Price Stock
5 mg €95.00 In Stock
25 mg €335.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €140.00 In Stock
2 x 25 mg €520.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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