An old drug with new applications. A Sulfa drug developed in 1950s and used in the treatment of inflammatory bowel disease and rheumatoid arthritis. This old drug was found in recent study to reverse severe liver disease. Sulfasalazine (SSZ) is a potent and selective inhibitor of NF-κB activation via its ability to block the activity of the inhibitor of κB (IκB) kinases α and β (IKKα and IKKβ). Sulfasalazine stimulates apoptosis of activated hepatic stellate cells and recovery from CCl4-induced fibrosis