MALT1 inhibitor MI-2

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2054

CAS [1047953-91-2]

MF C19H17Cl3N4O3
MW 455.72

Purity: 100%
Soluble in DMSO

MALT1 inhibitor MI-2

Description

Highly potent and selective MALT1 inhibitor; MI-2 binds directly to MALT1 and suppresses activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) in vitro and in vivo. MI-2 is notably nontoxic to mice

L Fontan et al. MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell. 2012, 22(6), 812-24.

RM Young & LM Staudt. A New “Brew” of MALT1 Inhibitors. Cancer Cell, 2012, 22(6), 706-707.

DJ Burgess. Anticancer drugs: Assault on MALT1. Nature Reviews Drug Discovery, 2013, 12(2), 100-101.

Highly potent and selective MALT1 inhibitor

Chemical name

2-chloro-N-(4-(5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl)phenyl)acetamide

Parent CAS No.

[1047953-91-2]

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MALT1 inhibitor MI-2

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MALT1 inhibitor MI-2

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