PF 04981517 - CYP3cide | PF 4981517

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2026

CAS [1390637-82-7]

MF C26H32N8
MW 456.59

Purity: 98%
Optical purity: Optically pure
Soluble in 0.1N HCl(aq) and DMSO

PF 04981517

Description

Potent and selective inhibitor of Cytochrome P450 3A4 (CYP3A4) with IC50 value of 30 nM; inactivates human CYP3A4 in an efficient and time-dependent manner

RL Walksky et al. Selective mechanism-based inactivation of CYP3A4 by CYP3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of CYP3A4 versus CYP3A5 in (...). Drug Metab. Dispos. 2012, 40(9), 1686-1697.

Inhibitor of Cytochrome P450 3A4 (CYP3A4)

Chemical name

(S)-1-methyl-3-(1-methyl-5-p-tolyl-1H-pyrazol-4-yl)-4-(3-(piperidin-1-yl)pyrrolidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine

Parent CAS No.

[1390637-82-7]

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PF 04981517 - CYP3cide | PF 4981517

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PF 04981517 - CYP3cide | PF 4981517

Description

Chemical name

Parent CAS No.

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